Scientific partnership with McGill University

A scientific partnership was concluded in 2017 with the School of Human Nutrition at McGill University. Their innovative comparative research made it possible to evaluate and quantify the peptides of AminoLock^® Collagen in comparison with a generic collagen hydrolyzate thanks to an analysis system simulating digestion.

McGill Research: AminoLock® Collagen Bioavailability

This collaborative research project with McGill University has demonstrated better bioavailability of AminoLock^® Collagen. In addition, it showed that several peptides important for joint health are better absorbed and metabolized than generic collagen. These essential peptides provided by our proprietary ingredient have been measured, along with their known joint health benefits, confirming that Genacol^® AminoLock^® Collagen is indeed different and unique.

1. Larder, C.E.; Iskandar, M.M.; Sabally, K.; Kubow, S. Complementary and efficient methods for di- and tri-peptide analysis and amino acid quantification from simulated gastrointestinal digestion of collagen hydrolysate. LWT 2022, 155, 112880, doi:https://doi.org/10.1016/j.lwt.2021.112880.

2.Larder, C.E.; Iskandar, M.M.; Kubow, S. Assessment of Bioavailability after In Vitro Digestion and First Pass Metabolism of Bioactive Peptides from Collagen Hydrolysates. Current Issues in Molecular Biology 2021, 43, 1592-1605, doi:10.3390/cimb43030113.

The scientific partnership with the team of Dr. Stan Kubow of the School of Human Nutrition at McGill University was concluded in 2017 and last 2 years. This collaborative research project made it possible to identify and quantify the bioavailability of certain key peptides after the complete process of digestion, absorption and metabolization between the AminoLock^® from Genacol^® and a generic hydrolyzed collagen supplement.

Dr. Kubow and his team have made certain observations:

The bioactive peptides Pro-Hyp, Gly-Pro, Hyp-Gly, and Ala-Hyp and Gly-Pro-Hyp from AminoLock® Collagen are absorbed and then transferred into the systemic circulation (first-pass metabolism);

Only the Gly-Pro-Hyp present in AminoLock^® Collagen is absorbed and then transferred into the systemic circulation. The peptide Gly-Pro-Hyp from the generic product does not undergo the first-pass effect and is therefore not bioavailable and will not reach the joints, so the effects associated with this peptide chain are therefore lost);

The peptides that reach the systemic circulation have significant permeability (absorption capacity). AminoLock® Collagen products also have better permeability of Gly-Pro-Hyp peptides compared with other collagen hydrolyzates from bovine sources and those from fish, which were compared;

Peptides are also metabolized by the liver before being released into the systemic circulation, but to different degrees depending on the product; Genacol^® unique collagen hydrolyzate is better metabolized than the generic: changes in the composition of the peptide chains, as well as a significant increase (around 40%) in the contents of Pro-Hyp, are observed there, but not in the generic collagen.

These results confirm that Genacol’s AminoLock Collagen is indeed different and unique, has better bioavailability, offers better absorption, and provides the body with key bioactive peptides for joint health.